Preparation of a Menthol/beta-Cyclodextrin Inclusion Complex Using Supercritical CO2
By: Lei, H. P
.
Contributor(s): Zhang, H | Ge, F. H.
Publisher: Mumbai Indian Journal of Pharmaceutical Science 2018Edition: Vol. 80 (04) July-August.Description: 766-771.Subject(s): PHARMACEUTICS | Supercritical fluid | Menthol | CharacteriztionOnline resources: Click here
In:
Indian journal of pharmaceutical sciencesSummary: A menthol/β-cyclodextrin inclusion complex was produced using supercritical CO2 while varying the temperature, pressure, co-solvent, inclusion time and depressurization time. The complex resulted was characterized with X-ray diffraction, scanning electron microscopy and differential scanning calorimetry. The characterization data confirmed the production of the inclusion complex at a maximum yield of 93.75 %. The dissolution rate of the complex was signiï¬?cantly higher than those of either untreated menthol or a physical mixture of menthol and β-cyclodextrin. This work thus demonstrated that supercritical CO2 could be successfully used to achieve inclusion complexes of menthol with β-CD.
| Item type | Current location | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
Articles Abstract Database
|
School of Pharmacy Archieval Section | Not for loan | 2018309 |
A menthol/β-cyclodextrin inclusion complex was produced using supercritical CO2 while varying the temperature, pressure, co-solvent, inclusion time and depressurization time. The complex resulted was characterized with X-ray diffraction, scanning electron microscopy and differential scanning calorimetry. The characterization data confirmed the production of the inclusion complex at a maximum yield of 93.75 %. The dissolution rate of the complex was signiï¬?cantly higher than those of either untreated menthol or a physical mixture of menthol and β-cyclodextrin. This work thus demonstrated that supercritical CO2 could be successfully used to achieve inclusion complexes of menthol with β-CD.
Click on an image to view it in the image viewer
There are no comments for this item.